| Literature DB >> 15163176 |
Ly T Phan1, Tianying Jian, Zhigang Chen, Yao-Ling Qiu, Zhaolin Wang, Theresa Beach, Alex Polemeropoulos, Yat Sun Or.
Abstract
Novel 4'-substituted 16-membered ring macrolides were synthesized by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4'-hydroxyl group. This new class of macrolide antibiotics exhibited potent activity against some key erythromycin-resistant pathogens.Entities:
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Year: 2004 PMID： 15163176 DOI： 10.1021/jm034233n
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446