Literature DB >> 15162223

Natural products active against African trypanosomes: a step towards new drugs.

Sara Hoet1, Frederik Opperdoes, Reto Brun, Joëlle Quetin-Leclercq.   

Abstract

This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp.,T congolense and T vivax) isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from he mid-1980s up to June 2003 is reviewed and 89 references are cited.

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Year:  2004        PMID： 15162223     DOI： 10.1039/b311021b

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  34 in total

1.  Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.

Authors:  Belinda S Hall; Emma Louise Meredith; Shane R Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  2012-09-04       Impact factor: 5.191

2.  Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.

Authors:  Gordon J Florence; Andrew L Fraser; Eoin R Gould; Elizabeth F B King; Stefanie K Menzies; Joanne C Morris; Lindsay B Tulloch; Terry K Smith
Journal:  ChemMedChem       Date:  2014-08-21       Impact factor: 3.466

Review 3.  Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis.

Authors:  Galina I Lepesheva; Michael R Waterman
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

4.  Wildtype and engineered monomeric triosephosphate isomerase from Trypanosoma brucei: partitioning of reaction intermediates in D2O and activation by phosphite dianion.

Authors:  M Merced Malabanan; Maybelle K Go; Tina L Amyes; John P Richard
Journal:  Biochemistry       Date:  2011-06-06       Impact factor: 3.162

5.  Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.

Authors:  Brad A Haubrich; Ujjal K Singha; Matthew B Miller; Craigen R Nes; Hosanna Anyatonwu; Laurence Lecordier; Presheet Patkar; David J Leaver; Fernando Villalta; Benoit Vanhollebeke; Minu Chaudhuri; W David Nes
Journal:  J Lipid Res       Date:  2014-11-25       Impact factor: 5.922

6.  In vivo antitrypanosomal effects of some ethnomedicinal plants from Nupeland of north central Nigeria.

Authors:  Abdullahi Mann; Oluwaseyi R Ifarajimi; Abdulfatai T Adewoye; Chidiebere Ukam; Ekpenyong E Udeme; Isaac I Okorie; Mohammed S Sakpe; Dauda R Ibrahim; Yusuf A Yahaya; Adamu Y Kabir; Emmanuel O Ogbadoyi
Journal:  Afr J Tradit Complement Altern Med       Date:  2010-10-02

7.  Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.

Authors:  Katharine R Watts; Joseline Ratnam; Kean-Hooi Ang; Karen Tenney; Jennifer E Compton; James McKerrow; Phillip Crews
Journal:  Bioorg Med Chem       Date:  2010-03-01       Impact factor: 3.641

8.  Anti-infective and cytotoxic properties of Bupleurum marginatum.

Authors:  Mohamed L Ashour; Mahmoud Z El-Readi; Razan Hamoud; Safaa Y Eid; Sherweit H El Ahmady; Endalkachew Nibret; Florian Herrmann; Mahmoud Youns; Ahmed Tahrani; Dorothea Kaufmann; Michael Wink
Journal:  Chin Med       Date:  2014-01-17       Impact factor: 5.455

9.  Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.

Authors:  Galina I Lepesheva; Robert D Ott; Tatiana Y Hargrove; Yuliya Y Kleshchenko; Inge Schuster; W David Nes; George C Hill; Fernando Villalta; Michael R Waterman
Journal:  Chem Biol       Date:  2007-11

10.  In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense.

Authors:  Thomas J Schmidt; Fernando B Da Costa; Norberto P Lopes; Marcel Kaiser; Reto Brun
Journal:  Antimicrob Agents Chemother       Date:  2013-10-28       Impact factor: 5.191
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