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Literature DB >> 15161563

Genetic alterations in prostate cancer.

Abstract

Prostate cancer is the number one malignancy among men. The search for causative factors has proven to be difficult and, accordingly, treatment options for advanced prostate cancer remain limited. However, technologic breakthroughs in the fields of genetics and molecular biology have advanced our understanding of the mechanisms involved in prostate carcinogenesis. The aim of this article is to review the most recent evidence for the role of various genetic insults at specific steps in tumor formation and to suggest potential therapeutic targets.

Entities: Chemical

Mesh：

Substances：
Neoplasm Proteins

Year: 2004 PMID： 15161563 DOI： 10.1007/s11934-004-0032-8

Source DB: PubMed Journal: Curr Urol Rep ISSN： 1527-2737 Impact factor: 2.862

80 in total

1. Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23.

Authors: J Xu; S L Zheng; G A Hawkins; D A Faith; B Kelly; S D Isaacs; K E Wiley; B Chang ; C M Ewing; P Bujnovszky; J D Carpten; E R Bleecker; P C Walsh; J M Trent; D A Meyers; W B Isaacs
Journal: Am J Hum Genet Date: 2001-07-06 Impact factor: 11.025

2. SRD5A2 gene polymorphisms and the risk of prostate cancer: a meta-analysis.

Authors: Christos Ntais; Anastasia Polycarpou; John P A Ioannidis
Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-07 Impact factor: 4.254

3. Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect.

Authors: T Habuchi; Z Liqing; T Suzuki; R Sasaki; N Tsuchiya; H Tachiki; N Shimoda; S Satoh; K Sato; Y Kakehi; T Kamoto; O Ogawa; T Kato
Journal: Cancer Res Date: 2000-10-15 Impact factor: 12.701

4. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

Authors: Minjung J Kim; Robert D Cardiff; Nishita Desai; Whitney A Banach-Petrosky; Ramon Parsons; Michael M Shen; Cory Abate-Shen
Journal: Proc Natl Acad Sci U S A Date: 2002-02-19 Impact factor: 11.205

5. Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

Authors: C Bowen; L Bubendorf; H J Voeller; R Slack; N Willi; G Sauter; T C Gasser; P Koivisto; E E Lack; J Kononen; O P Kallioniemi; E P Gelmann
Journal: Cancer Res Date: 2000-11-01 Impact factor: 12.701

6. Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus.

Authors: H Grönberg; S D Isaacs; J R Smith; J D Carpten; G S Bova; D Freije; J Xu; D A Meyers; F S Collins; J M Trent; P C Walsh; W B Isaacs
Journal: JAMA Date: 1997-10-15 Impact factor: 56.272

7. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.

Authors: J Li; C Yen; D Liaw; K Podsypanina; S Bose; S I Wang; J Puc; C Miliaresis; L Rodgers; R McCombie; S H Bigner; B C Giovanella; M Ittmann; B Tycko; H Hibshoosh; M H Wigler; R Parsons
Journal: Science Date: 1997-03-28 Impact factor: 47.728

8. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

Authors: T R Rebbeck; J M Jaffe; A H Walker; A J Wein; S B Malkowicz
Journal: J Natl Cancer Inst Date: 1998-08-19 Impact factor: 13.506

9. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

Authors: W H Lee; R A Morton; J I Epstein; J D Brooks; P A Campbell; G S Bova; W S Hsieh; W B Isaacs; W G Nelson
Journal: Proc Natl Acad Sci U S A Date: 1994-11-22 Impact factor: 11.205