OBJECTIVES: To investigate the decline per year in skin elasticity in postmenopausal women and how much hormone replacement therapy (HRT) increased elasticity over 12 months. DESIGN: Observational study of convenience sample. SETTING: The Cardiovascular Hospital of Central Japan, a cardiovascular medical center. PARTICIPANTS: One hundred seventy-six postmenopausal subjects, mean age+/-standard deviation=61.3+/-9.1. MEASUREMENTS: In Study 1, skin elasticity was measured in the right forearm using a suction device. Comparisons also were made with 45 premenopausal subjects (aged 34.5+/-9.9). Skin elasticity in the right forearm was measured using the same device at baseline and 12 months after initiation of HRT. INTERVENTIONS: In Study 2, 12 postmenopausal subjects (mean age=57.1+/-7.4, range 49-71) received conjugated equine estrogen (0.625 mg/d) in combination with medroxyprogesterone acetate (2.5 mg/d) for 12 months. RESULTS: In Study 1, significant negative correlations between skin elasticity and age and years since menopause were found (r=-0.60, P<.001 for each), as well as a 0.55% decline per year in skin elasticity. In Study 2, 12 months of HRT significantly increased skin elasticity in postmenopausal subjects, by 5.2%. CONCLUSION: After menopause, skin elasticity declined 0.55% per year; 12 months of HRT increased elasticity by 5.2%.
OBJECTIVES: To investigate the decline per year in skin elasticity in postmenopausal women and how much hormone replacement therapy (HRT) increased elasticity over 12 months. DESIGN: Observational study of convenience sample. SETTING: The Cardiovascular Hospital of Central Japan, a cardiovascular medical center. PARTICIPANTS: One hundred seventy-six postmenopausal subjects, mean age+/-standard deviation=61.3+/-9.1. MEASUREMENTS: In Study 1, skin elasticity was measured in the right forearm using a suction device. Comparisons also were made with 45 premenopausal subjects (aged 34.5+/-9.9). Skin elasticity in the right forearm was measured using the same device at baseline and 12 months after initiation of HRT. INTERVENTIONS: In Study 2, 12 postmenopausal subjects (mean age=57.1+/-7.4, range 49-71) received conjugated equine estrogen (0.625 mg/d) in combination with medroxyprogesterone acetate (2.5 mg/d) for 12 months. RESULTS: In Study 1, significant negative correlations between skin elasticity and age and years since menopause were found (r=-0.60, P<.001 for each), as well as a 0.55% decline per year in skin elasticity. In Study 2, 12 months of HRT significantly increased skin elasticity in postmenopausal subjects, by 5.2%. CONCLUSION: After menopause, skin elasticity declined 0.55% per year; 12 months of HRT increased elasticity by 5.2%.