| Literature DB >> 15161280 |
Yan Xu1, You Xin Zhang, Hiroshi Sugiyama, Tomoko Umano, Hideji Osuga, Kazuhiko Tanaka.
Abstract
Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA but also effectively converted the B-DNA conformation to Z-DNA. The enantioselectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.Entities:
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Year: 2004 PMID： 15161280 DOI： 10.1021/ja0499748
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419