Literature DB >> 15159488

Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.

D W Miller1, S M Hague, J Clarimon, M Baptista, K Gwinn-Hardy, M R Cookson, A B Singleton.   

Abstract

The authors recently demonstrated that genetic triplication of the SNCA locus causes Parkinson disease. Here it is shown that SNCA triplication results in a doubling in the amount of alpha-synuclein protein in blood. Examination of brain tissue showed a doubling in the level of SNCA message. However, at the protein level in brain, there was a greater effect on deposition of aggregated forms into insoluble fractions than on net expression of soluble alpha-synuclein.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15159488     DOI： 10.1212/01.wnl.0000127517.33208.f4

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  126 in total

1.  High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment.

Authors:  Patrícia Rosa; Sandra Tenreiro; Virginia Chu; Tiago F Outeiro; João Pedro Conde
Journal:  Biomicrofluidics       Date:  2012-02-09       Impact factor: 2.800

Review 2.  Recent advances in the genetics of Parkinson's disease.

Authors:  Ian Martin; Valina L Dawson; Ted M Dawson
Journal:  Annu Rev Genomics Hum Genet       Date:  2011       Impact factor: 8.929

3.  Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.

Authors:  Kavita Prasad; Elizabeth Tarasewicz; Pamela A Ohman Strickland; Michael O'Neill; Stephen N Mitchell; Kalpana Merchant; Samnang Tep; Kathryn Hilton; Akash Datwani; Manuel Buttini; Sarah Mueller-Steiner; Eric K Richfield
Journal:  Eur J Neurosci       Date:  2011-01-28       Impact factor: 3.386

4.  SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.

Authors:  Ignacio F Mata; Min Shi; Pinky Agarwal; Kathryn A Chung; Karen L Edwards; Stewart A Factor; Douglas R Galasko; Carmen Ginghina; Alida Griffith; Donald S Higgins; Denise M Kay; Hojoong Kim; James B Leverenz; Joseph F Quinn; John W Roberts; Ali Samii; Katherine W Snapinn; Debby W Tsuang; Dora Yearout; Jing Zhang; Haydeh Payami; Cyrus P Zabetian
Journal:  Arch Neurol       Date:  2010-11

Review 5.  Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?

Authors:  Pengfei Yang; Joel S Perlmutter; Tammie L S Benzinger; John C Morris; Jinbin Xu
Journal:  Ageing Res Rev       Date:  2019-11-22       Impact factor: 10.895

6.  α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons.

Authors:  Richard Ortega; Asuncion Carmona; Stéphane Roudeau; Laura Perrin; Tanja Dučić; Eleonora Carboni; Sylvain Bohic; Peter Cloetens; Paul Lingor
Journal:  Mol Neurobiol       Date:  2015-04-02       Impact factor: 5.590

7.  Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene.

Authors:  A Afek; L Tagliafierro; O C Glenn; D B Lukatsky; R Gordan; O Chiba-Falek
Journal:  Neurogenetics       Date:  2018-05-05       Impact factor: 2.660

8.  β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Authors:  Shuchi Mittal; Kjetil Bjørnevik; Doo Soon Im; Adrian Flierl; Xianjun Dong; Joseph J Locascio; Kristine M Abo; Elizabeth Long; Ming Jin; Bing Xu; Yang K Xiang; Jean-Christophe Rochet; Anders Engeland; Patrizia Rizzu; Peter Heutink; Tim Bartels; Dennis J Selkoe; Barbara J Caldarone; Marcie A Glicksman; Vikram Khurana; Birgitt Schüle; David S Park; Trond Riise; Clemens R Scherzer
Journal:  Science       Date:  2017-09-01       Impact factor: 47.728

9.  The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.

Authors:  Colton Linnertz; Michael W Lutz; John F Ervin; Jawara Allen; Natalie R Miller; Kathleen A Welsh-Bohmer; Allen D Roses; Ornit Chiba-Falek
Journal:  Hum Mol Genet       Date:  2014-04-28       Impact factor: 6.150

10.  GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.

Authors:  Clemens R Scherzer; Jeffrey A Grass; Zhixiang Liao; Imelda Pepivani; Bin Zheng; Aron C Eklund; Paul A Ney; Juliana Ng; Meghan McGoldrick; Brit Mollenhauer; Emery H Bresnick; Michael G Schlossmacher
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-31       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.