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Literature DB >> 15159206

Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals.

Shunichi Terasaka¹, Yukie Aita, Akio Inoue, Shinichi Hayashi, Michiko Nishigaki, Kazuhiko Aoyagi, Hiroki Sasaki, Yuko Wada-Kiyama, Yasuo Sakuma, Shuichi Akaba, Junko Tanaka, Hideko Sone, Junzo Yonemoto, Masao Tanji, Ryoiti Kiyama.

Abstract

We developed a DNA microarray to evaluate the estrogen activity of natural estrogens and industrial chemicals. Using MCF-7 cells, we conducted a comprehensive analysis of estrogen-responsive genes among approximately 20,000 human genes. On the basis of reproducible and reliable responses of the genes to estrogen, we selected 172 genes to be used for developing a customized DNA microarray. Using this DNA microarray, we examined estrogen activity among natural estrogens (17beta-estradiol, estriol, estrone, genistein), industrial chemicals (diethylstilbestrol, bisphenol A, nonylphenol, methoxychlor), and dioxin. We obtained results identical to those for other bioassays that are used for detecting estrogen activity. On the basis of statistical correlations analysis, these bioassays have shown more sensitivity for dioxin and methoxychlor.

Entities: CellLine Chemical Gene Species

Mesh：

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Year: 2004 PMID： 15159206 PMCID： PMC1241992 DOI： 10.1289/ehp.6753

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

40 in total

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9. The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells.

Authors: Adele Vivacqua; Anna Grazia Recchia; Giovanna Fasanella; Sabrina Gabriele; Amalia Carpino; Vittoria Rago; Maria Luisa Di Gioia; Antonella Leggio; Daniela Bonofiglio; Angelo Liguori; Marcello Maggiolini
Journal: Endocrine Date: 2003-12 Impact factor: 3.633

10. Estrogenic activity of an environmental pollutant, 2-nitrofluorene, after metabolic activation by rat liver microsomes.

Authors: Takashi Fujimoto; Shigeyuki Kitamura; Seigo Sanoh; Kazumi Sugihara; Shin'ichi Yoshihara; Nariaki Fujimoto; Shigeru Ohta
Journal: Biochem Biophys Res Commun Date: 2003-04-04 Impact factor: 3.575

26 in total

1. Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos.

Authors: Eunah Chung; Maria C Genco; Laura Megrelis; Joan V Ruderman
Journal: Proc Natl Acad Sci U S A Date: 2011-10-17 Impact factor: 11.205

2. Computational method for discovery of estrogen responsive genes.

Authors: Suisheng Tang; Sin Lam Tan; Suresh Kumar Ramadoss; Arun Prashanth Kumar; Man-Hung Eric Tang; Vladimir B Bajic
Journal: Nucleic Acids Res Date: 2004-12-01 Impact factor: 16.971

3. Importance of dosage standardization for interpreting transcriptomal signature profiles: evidence from studies of xenoestrogens.

Authors: Toshi Shioda; Jessica Chesnes; Kathryn R Coser; Lihua Zou; Jingyung Hur; Kathleen L Dean; Carlos Sonnenschein; Ana M Soto; Kurt J Isselbacher
Journal: Proc Natl Acad Sci U S A Date: 2006-08-01 Impact factor: 11.205

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Authors: Li-Hua Song; Hong-Li Yan; Dong-Lian Cai
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Review 5. DNA microarray-based gene expression profiling of estrogenic chemicals.

Authors: Ryoiti Kiyama; Yun Zhu
Journal: Cell Mol Life Sci Date: 2014-01-08 Impact factor: 9.261

6. Designing Endocrine Disruption Out of the Next Generation of Chemicals.

Authors: T T Schug; R Abagyan; B Blumberg; T J Collins; D Crews; P L DeFur; S M Dickerson; T M Edwards; A C Gore; L J Guillette; T Hayes; J J Heindel; A Moores; H B Patisaul; T L Tal; K A Thayer; L N Vandenberg; J Warner; C S Watson; F S Vom Saal; R T Zoeller; K P O'Brien; J P Myers
Journal: Green Chem Date: 2013-01 Impact factor: 10.182