| Literature DB >> 15158981 |
Y M Fan1, L Z Xu, J Gao, Y Wang, X H Tang, X N Zhao, Z X Zhang.
Abstract
The antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the antiinflammatory activity of T. catappa leaves. Copyright 2004 Elsevier B.V.Entities:
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Year: 2004 PMID： 15158981 DOI： 10.1016/j.fitote.2003.11.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882