Literature DB >> 15158970

Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

D Wang1, W Li, M Pechar, P Kopecková, D Brömme, J Kopecek.   

Abstract

The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

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Year:  2004        PMID: 15158970     DOI: 10.1016/j.ijpharm.2003.03.003

Source DB:  PubMed          Journal:  Int J Pharm        ISSN: 0378-5173            Impact factor:   5.875


  5 in total

Review 1.  Targeting polymer therapeutics to bone.

Authors:  Stewart A Low; Jindřich Kopeček
Journal:  Adv Drug Deliv Rev       Date:  2012-01-28       Impact factor: 15.470

Review 2.  Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates.

Authors:  Blessing Aderibigbe; Isiaka Aderibigbe; Patricia Popoola
Journal:  Pharmaceutics       Date:  2016-12-26       Impact factor: 6.321

Review 3.  Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery.

Authors:  Natalie Fuchs; Mergim Meta; Detlef Schuppan; Lutz Nuhn; Tanja Schirmeister
Journal:  Cells       Date:  2020-09-02       Impact factor: 6.600

Review 4.  Exploring the role of cathepsin in rheumatoid arthritis.

Authors:  Tapan Behl; Swati Chadha; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Rajwinder Kaur; Saurabh Bhatia; Ahmed Al-Harrasi; Sridevi Chigurupati; Ahmed Alhowail; Simona Bungau
Journal:  Saudi J Biol Sci       Date:  2021-09-13       Impact factor: 4.219

Review 5.  Advances in the discovery of cathepsin K inhibitors on bone resorption.

Authors:  Jun Lu; Maolin Wang; Ziyue Wang; Zhongqi Fu; Aiping Lu; Ge Zhang
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

  5 in total

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