| Literature DB >> 15157666 |
Franck Verrecchia1, Alain Mauviel.
Abstract
The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. It also represents the most crucial element governing the process of tissue repair. The synthesis of type I collagen gene is highly regulated by different cytokines at the transcriptional level. Especially, transforming growth factor beta (TGF-beta), a key player in the physiopathology of tissue repair, enhances type I collagen gene expression. In contrast, tumor necrosis factor alpha (TNF-alpha), whose matrix-remodelling function is opposite to that of TGF-beta, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-beta and TNF-alpha and on the molecular mechanisms that control the antagonistic activity of TNF-alpha against TGF-beta-driven type I collagen gene expression.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15157666 DOI： 10.1016/j.cellsig.2004.02.007
Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315