Literature DB >> 15157657

6-Dimethylaminopurine (6-DMAP), which is used to produce most cloned animals, is mutagenic in Salmonella typhimurium TA1535.

Motoe Katoh1, Akihiro Araki, Takahiro Ogura, Ruby P A Valdivia.   

Abstract

6-Dimethylaminopurine (6-DMAP) and cycloheximide have recently been used for successful production of cloned mammals. We investigated whether 6-DMAP or cycloheximide are mutagenic agents in the Ames test. Whereas cycloheximide showed no differences compared to the negative control in any of the tester strains, 6-DMAP was clearly mutagenic in Salmonella typhimurium strain TA1535. Here, we strongly propose that innocuous chemicals be used in the production of cloned animals.

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Year:  2004        PMID： 15157657     DOI： 10.1016/j.mrgentox.2004.03.003

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  3 in total

1.  Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors.

Authors:  Robin L Webb; Kirk A Findlay; Michael A Green; Tina L Beckett; M Paul Murphy
Journal:  PLoS One       Date:  2010-03-19       Impact factor: 3.240

2.  Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo.

Authors:  R J Oliveira; M S Mantovani; A F da Silva; J R Pesarini; M O Mauro; L R Ribeiro
Journal:  Braz J Med Biol Res       Date:  2014-03-28       Impact factor: 2.590

3.  Double cytoplast embryonic cloning improves in vitro but not in vivo development from mitotic pluripotent cells in cattle.

Authors:  Sarah Jane Appleby; Pavla Misica-Turner; Fleur Catherine Oback; Arindam Dhali; Zachariah Louis McLean; Björn Oback
Journal:  Front Genet       Date:  2022-09-28       Impact factor: 4.772
  3 in total

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