Literature DB >> 15157603

Interaction of mitochondrial voltage-dependent anion channel from rat brain with plasminogen protein leads to partial closure of the channel.

Jyotirmoy Banerjee1, Subhendu Ghosh.   

Abstract

Voltage-dependent anion channel (VDAC) is reported to be the receptor for plasminogen kringle5. In this paper, the interaction of VDAC from rat brain mitochondria with plasminogen protein has been investigated through bilayer electrophysiological studies. We report for the first time that interaction of plasminogen with VDAC leads to partial closure of the channel on a lipid bilayer. This could be a mechanism of modulation of VDAC gating in a cellular system.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15157603     DOI： 10.1016/j.bbamem.2004.02.005

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator.

Authors:  Jianxue Li; Yinghua Ma; Yang D Teng; Kangni Zheng; Timothy K Vartanian; Evan Y Snyder; Richard L Sidman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-08       Impact factor: 11.205

2.  The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface.

Authors:  Mario Gonzalez-Gronow; Rupa Ray; Fang Wang; Salvatore V Pizzo
Journal:  J Biol Chem       Date:  2012-11-16       Impact factor: 5.157

3.  Tissue plasminogen activator regulates Purkinje neuron development and survival.

Authors:  Jianxue Li; Lili Yu; Xuesong Gu; Yinghua Ma; Renata Pasqualini; Wadih Arap; Evan Y Snyder; Richard L Sidman
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-14       Impact factor: 11.205

4.  Quinidine partially blocks mitochondrial voltage-dependent anion channel (VDAC).

Authors:  Chetan Malik; Subhendu Ghosh
Journal:  Eur Biophys J       Date:  2020-03-09       Impact factor: 1.733
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.