Literature DB >> 15157602

Theoretical conformation of the closed and open states of the acetylcholine receptor channel.

Ben Corry1.   

Abstract

We conduct a theoretical analysis to show the recently imaged structure of the acetylcholine receptor pore is in a non-conducting state. A hypothesised open state consistent with a lower resolution image is created and shown to have high conductance.

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Year:  2004        PMID： 15157602     DOI： 10.1016/j.bbamem.2004.02.006

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  Homology model of the GABAA receptor examined using Brownian dynamics.

Authors:  Megan O'Mara; Brett Cromer; Michael Parker; Shin-Ho Chung
Journal:  Biophys J       Date:  2005-03-04       Impact factor: 4.033

2.  A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor.

Authors:  Richard J Law; Richard H Henchman; J Andrew McCammon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-27       Impact factor: 11.205

Review 3.  Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor.

Authors:  Antoine Taly
Journal:  Eur Biophys J       Date:  2007-07-04       Impact factor: 1.733

4.  GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

Authors:  Jamie A Ashby; Ian V McGonigle; Kerry L Price; Netta Cohen; Federico Comitani; Dennis A Dougherty; Carla Molteni; Sarah C R Lummis
Journal:  Biophys J       Date:  2012-11-20       Impact factor: 4.033

5.  Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain.

Authors:  Richard H Henchman; Hai-Long Wang; Steven M Sine; Palmer Taylor; J Andrew McCammon
Journal:  Biophys J       Date:  2005-01-21       Impact factor: 4.033

6.  An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.

Authors:  Ben Corry
Journal:  Biophys J       Date:  2005-11-11       Impact factor: 4.033

7.  Computational study of the transmembrane domain of the acetylcholine receptor.

Authors:  Chen Song; Ben Corry
Journal:  Eur Biophys J       Date:  2009-05-23       Impact factor: 1.733

8.  Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions.

Authors:  Andrew Hung; Kaihsu Tai; Mark S P Sansom
Journal:  Biophys J       Date:  2005-02-18       Impact factor: 4.033

Review 9.  Structural answers and persistent questions about how nicotinic receptors work.

Authors:  Gregg B Wells
Journal:  Front Biosci       Date:  2008-05-01

10.  Ion channel gates: comparative analysis of energy barriers.

Authors:  Kaihsu Tai; Shozeb Haider; Alessandro Grottesi; Mark S P Sansom
Journal:  Eur Biophys J       Date:  2008-10-16       Impact factor: 1.733
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