BACKGROUND: Studies on Helicobacter pylori genotypes have focused on adults in developed countries, and data on the genotypes of Helicobacter pylori recovered from the children are rare. MATERIALS AND METHODS: One hundred and twenty-eight biopsy samples from patients with H. pylori infection were studied. The patients' ages ranged from 9 to 83 years. PCR analysis for vacA genotypes was performed using DNA extracted from biopsy specimens. RESULTS: Genotyping of the s-region showed s1a in 33 (25.8%) samples and s1c in 82 (64.1%) samples. When the specimens were grouped by age, the distribution of s-region genotype was found to be significantly different between groups (p = .002). The prevalence of s1a was 45.2% in patients < 20 years old, but 14.9% in patients > or = 50 years old. On the other hand, the prevalence of s1c or recombinant s1a-s1c was higher in those > or = 50 years old. The distribution of the m-region did not differ significantly with age (p = .110). CONCLUSIONS: Strain populations infecting Korean adults and children differ.
BACKGROUND: Studies on Helicobacter pylori genotypes have focused on adults in developed countries, and data on the genotypes of Helicobacter pylori recovered from the children are rare. MATERIALS AND METHODS: One hundred and twenty-eight biopsy samples from patients with H. pyloriinfection were studied. The patients' ages ranged from 9 to 83 years. PCR analysis for vacA genotypes was performed using DNA extracted from biopsy specimens. RESULTS: Genotyping of the s-region showed s1a in 33 (25.8%) samples and s1c in 82 (64.1%) samples. When the specimens were grouped by age, the distribution of s-region genotype was found to be significantly different between groups (p = .002). The prevalence of s1a was 45.2% in patients < 20 years old, but 14.9% in patients > or = 50 years old. On the other hand, the prevalence of s1c or recombinant s1a-s1c was higher in those > or = 50 years old. The distribution of the m-region did not differ significantly with age (p = .110). CONCLUSIONS: Strain populations infecting Korean adults and children differ.
Authors: Yon Ho Choe; Jee Hyun Lee; Hae Jeong Lee; Kyung Hoon Paik; Dong Kyu Jin; Sang Yong Song; Jun Haeng Lee Journal: Gut Liver Date: 2007-12-31 Impact factor: 4.519
Authors: Onelkis Feliciano; Oderay Gutierrez; Lidunka Valdés; Trini Fragoso; Ana Maria Calderin; Antonio Eduardo Valdes; Rafael Llanes Journal: Biomed Res Int Date: 2015-04-06 Impact factor: 3.411