| Literature DB >> 15156141 |
Angela H Ting1, Kam-wing Jair, Hiromu Suzuki, Ray-Whay Chiu Yen, Stephen B Baylin, Kornel E Schuebel.
Abstract
The role of the primary mammalian DNA methyltransferase, DNMT1, in maintaining CpG island methylation in human colon cancer cells has recently been questioned. This controversy has arisen from discrepancies between genetic knockout and RNA interference-mediated knockdown studies. Here, we re-examined the RNA interference-based approach and found that hypermethylation of single-copy genes is maintained in cells transiently and stably depleted of DNMT1.Entities:
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Year: 2004 PMID： 15156141 DOI： 10.1038/ng1365
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330