BACKGROUND: Pre-eclampsia shares a number of risk factors with cardiovascular disease (CVD). Women with recurrent pre-eclampsia or pre-eclampsia early in pregnancy reportedly have an increased long-term risk of CVD. Short stature is a risk factor for CVD but has rarely been examined in relation to pre-eclampsia. METHODS: We used data from 59 968 singleton live births in the Danish National Birth Cohort born between 1998 and 2001 to assess risk of severe pre-eclampsia/eclampsia (296 cases) in relation to self-reported height. We examined the association in multiple logistic regressions stratified by parity. RESULTS: Among primiparas there was a weak association (compared with women <165 cm, women >172 cm had on OR of 0.79, 95% CI: 0.55, 1.14). Among multiparas, the tallest women had an adjusted OR of 0.42 (95% CI: 0.20, 0.87) of developing severe pre-eclampsia compared with women <165 cm. The OR per centimetre was 0.94 (95% CI: 0.91, 0.97). Self-reported pre-existing hypertension did not explain this association, which also persisted when the analysis was restricted to non-overweight women. CONCLUSIONS: Short stature was associated with a higher risk of severe pre-eclampsia in multiparas participating in the Danish National Birth Cohort.
BACKGROUND: Pre-eclampsia shares a number of risk factors with cardiovascular disease (CVD). Women with recurrent pre-eclampsia or pre-eclampsia early in pregnancy reportedly have an increased long-term risk of CVD. Short stature is a risk factor for CVD but has rarely been examined in relation to pre-eclampsia. METHODS: We used data from 59 968 singleton live births in the Danish National Birth Cohort born between 1998 and 2001 to assess risk of severe pre-eclampsia/eclampsia (296 cases) in relation to self-reported height. We examined the association in multiple logistic regressions stratified by parity. RESULTS: Among primiparas there was a weak association (compared with women <165 cm, women >172 cm had on OR of 0.79, 95% CI: 0.55, 1.14). Among multiparas, the tallest women had an adjusted OR of 0.42 (95% CI: 0.20, 0.87) of developing severe pre-eclampsia compared with women <165 cm. The OR per centimetre was 0.94 (95% CI: 0.91, 0.97). Self-reported pre-existing hypertension did not explain this association, which also persisted when the analysis was restricted to non-overweight women. CONCLUSIONS: Short stature was associated with a higher risk of severe pre-eclampsia in multiparas participating in the Danish National Birth Cohort.
Authors: Clarice R Weinberg; Min Shi; Olga Basso; Lisa A DeRoo; Quaker Harmon; Allen J Wilcox; Rolv Skjærven Journal: Environ Health Perspect Date: 2017-06-29 Impact factor: 9.031
Authors: Johan Wadén; Carol Forsblom; Lena M Thorn; Markku Saraheimo; Milla Rosengård-Bärlund; Outi Heikkilä; Kustaa Hietala; Ken Ong; Nicholas Wareham; Per-Henrik Groop Journal: Diabetes Date: 2009-06-02 Impact factor: 9.461