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Literature DB >> 15155685

Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells.

Catherine M Greene¹, Noel G McElvaney, Shane J O'Neill, Clifford C Taggart.

Abstract

Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-kappaB activation. We examined its ability to inhibit NF-kappaB activation induced by lipoteichoic acid and investigated the effects of oxidation or complex formation with neutrophil elastase on SLPI's anti-inflammatory properties in U937 myelomonocytic cells and macrophages.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2004 PMID： 15155685 PMCID： PMC415654 DOI： 10.1128/IAI.72.6.3684-3687.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

30 in total

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