Literature DB >> 15155676

The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans.

Christina M Hull1, Gary M Cox, Joseph Heitman.   

Abstract

Cryptococcus neoformans is a human fungal pathogen that has two mating types (a and alpha). Experiments have shown that in some backgrounds alpha strains are more virulent than a strains. Our studies reveal that the only known alpha-specific factor, SXI1alpha, is not necessary for virulence.

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Year:  2004        PMID： 15155676      PMCID： PMC415721          DOI： 10.1128/IAI.72.6.3643-3645.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Molecular epidemiology of Cryptococcus neoformans in Brazil and the United States: evidence for both local genetic differences and a global clonal population structure.

Authors:  S P Franzot; J S Hamdan; B P Currie; A Casadevall
Journal:  J Clin Microbiol       Date:  1997-09       Impact factor: 5.948

2.  Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha.

Authors:  Christina M Hull; Robert C Davidson; Joseph Heitman
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

3.  Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type.

Authors:  B L Wickes; M E Mayorga; U Edman; J C Edman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

4.  Distribution of alpha and alpha mating types of Cryptococcus neoformans among natural and clinical isolates.

Authors:  K J Kwon-Chung; J E Bennett
Journal:  Am J Epidemiol       Date:  1978-10       Impact factor: 4.897

5.  Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.

Authors:  K B Lengeler; P Wang; G M Cox; J R Perfect; J Heitman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

6.  A PCR-based strategy to generate integrative targeting alleles with large regions of homology.

Authors:  Robert C Davidson; Jill R Blankenship; Peter R Kraus; Marisol de Jesus Berrios; Christina M Hull; Cletus D'Souza; Ping Wang; Joseph Heitman
Journal:  Microbiology       Date:  2002-08       Impact factor: 2.777

7.  Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans.

Authors:  K J Kwon-Chung
Journal:  Mycologia       Date:  1976 Jul-Aug       Impact factor: 2.696

8.  Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.

Authors:  Kirsten Nielsen; Gary M Cox; Ping Wang; Dena L Toffaletti; John R Perfect; Joseph Heitman
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

9.  Genetic association of mating types and virulence in Cryptococcus neoformans.

Authors:  K J Kwon-Chung; J C Edman; B L Wickes
Journal:  Infect Immun       Date:  1992-02       Impact factor: 3.441
  9 in total
  14 in total

1.  Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.

Authors:  Kirsten Nielsen; Gary M Cox; Anastasia P Litvintseva; Eleftherios Mylonakis; Stephanie D Malliaris; Daniel K Benjamin; Steven S Giles; Thomas G Mitchell; Arturo Casadevall; John R Perfect; Joseph Heitman
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

2.  Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans.

Authors:  Xiaorong Lin; Kirsten Nielsen; Sweta Patel; Joseph Heitman
Journal:  Infect Immun       Date:  2008-04-21       Impact factor: 3.441

3.  A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans.

Authors:  Cheryl D Chun; Jessica C S Brown; Hiten D Madhani
Journal:  Cell Host Microbe       Date:  2011-03-17       Impact factor: 21.023

4.  Targets of the Sex Inducer homeodomain proteins are required for fungal development and virulence in Cryptococcus neoformans.

Authors:  Matthew E Mead; Brynne C Stanton; Emilia K Kruzel; Christina M Hull
Journal:  Mol Microbiol       Date:  2015-01-16       Impact factor: 3.501

5.  Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans.

Authors:  Cheryl D Chun; Hiten D Madhani
Journal:  Methods Enzymol       Date:  2010-03-01       Impact factor: 1.600

6.  Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans.

Authors:  Christina M Hull; Marie-Josee Boily; Joseph Heitman
Journal:  Eukaryot Cell       Date:  2005-03

7.  Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.

Authors:  Oliver W Liu; Cheryl D Chun; Eric D Chow; Changbin Chen; Hiten D Madhani; Suzanne M Noble
Journal:  Cell       Date:  2008-10-03       Impact factor: 41.582

Review 8.  Transcriptional control of sexual development in Cryptococcus neoformans.

Authors:  Matthew E Mead; Christina M Hull
Journal:  J Microbiol       Date:  2016-04-20       Impact factor: 3.422

Review 9.  Fungal sex and pathogenesis.

Authors:  Geraldine Butler
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

10.  Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system.

Authors:  Hsiang-Kuang Tseng; Chang-Pan Liu; Michael S Price; Ambrose Y Jong; Jui-Chih Chang; Dena L Toffaletti; Marisol Betancourt-Quiroz; Aubrey E Frazzitta; Wen-Long Cho; John R Perfect
Journal:  PLoS One       Date:  2012-09-20       Impact factor: 3.240
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