Literature DB >> 15155117

Investigating cardiovascular risk reduction--the Rosuvastatin GALAXY Programme.

Herbert Schuster1, Jonathan C Fox.   

Abstract

The GALAXY Programme is a comprehensive global research initiative that will address several important unanswered questions in statin research and investigate the impact of rosuvastatin on cardiovascular risk reduction and patient outcomes. Studies already completed demonstrate that rosuvastatin provides greater reductions in low-density lipoprotein cholesterol (LDL-C) than other statins, enabling more patients to achieve LDL-C treatment goals. Additionally, rosuvastatin provides beneficial effects on other components of the atherogenic lipid profile. Ongoing studies will evaluate whether these effects translate into beneficial effects on atherosclerosis and significant reductions in cardiovascular events. Important information will also be provided on the role of statins in less well studied groups, including patients with heart failure, end stage renal disease, and individuals without elevated LDL-C but at heightened vascular risk as a result of increased systemic inflammation. Ultimately, the GALAXY Programme will provide clinical data that will enable physicians to make more effective statin treatment decisions, which will lead to improved patient care and cardiovascular outcomes.

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Year:  2004        PMID: 15155117     DOI: 10.1517/14656566.5.5.1187

Source DB:  PubMed          Journal:  Expert Opin Pharmacother        ISSN: 1465-6566            Impact factor:   3.889


  9 in total

Review 1.  Rationale for combination therapy with statin drugs in the treatment of dyslipidemia.

Authors:  Benjamin J Ansell
Journal:  Curr Atheroscler Rep       Date:  2005-02       Impact factor: 5.113

2.  Rosuvastatin versus atorvastatin in achieving lipid goals in patients at high risk for cardiovascular disease in clinical practice: A randomized, open-label, parallel-group, multicenter study (DISCOVERY Alpha study).

Authors:  Azan S Binbrek; Avishay Elis; Muayed Al-Zaibag; Jaan Eha; Irena Keber; Ada M Cuevas; Swati Mukherjee; Thomas R Miller
Journal:  Curr Ther Res Clin Exp       Date:  2006-01

3.  Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study.

Authors:  Christian Berne; Annica Siewert-Delle
Journal:  Cardiovasc Diabetol       Date:  2005-06-03       Impact factor: 9.951

4.  Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high-risk patients with hypercholesterolemia--Prospective study to evaluate the Use of Low doses of the Statins Atorvastatin and Rosuvastatin (PULSAR).

Authors:  Michael B Clearfield; John Amerena; Jean-Pierre Bassand; Hugo R Hernández García; Sam S Miller; Froukje F M Sosef; Michael K Palmer; Brian S Bryzinski
Journal:  Trials       Date:  2006-12-21       Impact factor: 2.279

Review 5.  Statins in the treatment of chronic heart failure: a systematic review.

Authors:  Pim van der Harst; Adriaan A Voors; Wiek H van Gilst; Michael Böhm; Dirk J van Veldhuisen
Journal:  PLoS Med       Date:  2006-08       Impact factor: 11.069

Review 6.  Ongoing clinical trials of the pleiotropic effects of statins.

Authors:  Jean Davignon; Lawrence A Leiter
Journal:  Vasc Health Risk Manag       Date:  2005

7.  The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393].

Authors: 
Journal:  BMC Med       Date:  2005-03-16       Impact factor: 8.775

Review 8.  Racial Differences in the Cholesterol-Lowering Effect of Statin.

Authors:  Ryo Naito; Katsumi Miyauchi; Hiroyuki Daida
Journal:  J Atheroscler Thromb       Date:  2016-10-12       Impact factor: 4.928

9.  Effectiveness of statins in Medicare-eligible patients and patients < 65 years using clinical practice data.

Authors:  K M Fox; S K Gandhi; R L Ohsfeldt; J W Blasetto; M H Davidson
Journal:  Int J Clin Pract       Date:  2007-10       Impact factor: 2.503

  9 in total

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