BACKGROUND: One of the most often used complementary or alternative anticancer therapeutics for breast cancer is mistletoe extract with Viscum album lectin (VAA-1) as the leading component. The aim of this study was to determine the correlation between VAA-1 binding in breast cancer and disease outcome. MATERIALS AND METHODS: VAA-1 binding to either tumour cells or tumour infiltrating inflammatory cells was examined by immunohistochemical staining of paraffin tissue sections from breast cancer patients (n=226). RESULTS: About 34% of breast cancer tumour cells displayed a strong VAA-1 binding. Kaplan-Meier statistics revealed an inverse correlation between disease outcome and presence of strong VAA-1 binding to tumour cells. CONCLUSION: As binding of VAA-1 indicates the presence of galactose molecules in saccharide structures of the cytoplasm or cell membrane, we conclude that the amount of galactose-containing glycoproteins, mucoproteins and glycolipids in breast cancer tumour cells is related to disease outcome.
BACKGROUND: One of the most often used complementary or alternative anticancer therapeutics for breast cancer is mistletoe extract with Viscum album lectin (VAA-1) as the leading component. The aim of this study was to determine the correlation between VAA-1 binding in breast cancer and disease outcome. MATERIALS AND METHODS: VAA-1 binding to either tumour cells or tumour infiltrating inflammatory cells was examined by immunohistochemical staining of paraffin tissue sections from breast cancerpatients (n=226). RESULTS: About 34% of breast cancer tumour cells displayed a strong VAA-1 binding. Kaplan-Meier statistics revealed an inverse correlation between disease outcome and presence of strong VAA-1 binding to tumour cells. CONCLUSION: As binding of VAA-1 indicates the presence of galactose molecules in saccharide structures of the cytoplasm or cell membrane, we conclude that the amount of galactose-containing glycoproteins, mucoproteins and glycolipids in breast cancer tumour cells is related to disease outcome.
Authors: Lily Anne Y Welty; Eileen L Heinrich; Karina Garcia; Lisa R Banner; Michael L Summers; Larry Baresi; Stan Metzenberg; Cathy Coyle-Thompson; Steven B Oppenheimer Journal: Acta Histochem Date: 2006-01-18 Impact factor: 2.479
Authors: Maria B C de Matos; Roel Deckers; Benjamin van Elburg; Guillaume Lajoinie; Bárbara S de Miranda; Michel Versluis; Raymond Schiffelers; Robbert J Kok Journal: Front Pharmacol Date: 2019-12-05 Impact factor: 5.810