Literature DB >> 15153438

Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.

Rüdiger Göke1, Cornelia Gregel, Alexandra Göke, Rudolf Arnold, Harald Schmidt, Brigitte Lankat-Buttgereit.   

Abstract

PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.

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Year:  2004        PMID： 15153438     DOI： 10.1196/annals.1294.024

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  19 in total

1.  Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.

Authors:  Arti B Gaur; Susan L Holbeck; Nancy H Colburn; Mark A Israel
Journal:  Neuro Oncol       Date:  2011-06       Impact factor: 12.300

2.  Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA.

Authors:  K Eto; S Goto; W Nakashima; Y Ura; S-I Abe
Journal:  Cell Death Differ       Date:  2011-09-30       Impact factor: 15.828

Review 3.  Pathologic research update of colorectal neuroendocrine tumors.

Authors:  Shu-Juan Ni; Wei-Qi Sheng; Xiang Du
Journal:  World J Gastroenterol       Date:  2010-04-14       Impact factor: 5.742

4.  An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease.

Authors:  Xiaojun Liu; Yunhui Cheng; Jian Yang; Thomas J Krall; Yuqing Huo; Chunxiang Zhang
Journal:  Am J Physiol Cell Physiol       Date:  2010-03-31       Impact factor: 4.249

5.  Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.

Authors:  Vishalakshi Nanjappa; Santosh Renuse; Gajanan J Sathe; Remya Raja; Nazia Syed; Aneesha Radhakrishnan; Tejaswini Subbannayya; Arun Patil; Arivusudar Marimuthu; Nandini A Sahasrabuddhe; Rafael Guerrero-Preston; Babu L Somani; Bipin Nair; Gopal C Kundu; T Keshava Prasad; Joseph A Califano; Harsha Gowda; David Sidransky; Akhilesh Pandey; Aditi Chatterjee
Journal:  Cancer Biol Ther       Date:  2015-09-21       Impact factor: 4.742

6.  An essential role of PDCD4 in progression and malignant proliferation of gastrointestinal stromal tumors.

Authors:  Lingling Ding; Xia Zhang; Miaoqing Zhao; Zhonghua Qu; Shanying Huang; Mei Dong; Fei Gao
Journal:  Med Oncol       Date:  2011-08-18       Impact factor: 3.064

7.  Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.

Authors:  Hsin-Sheng Yang; Connie P Matthews; Timothy Clair; Qing Wang; Alyson R Baker; Chou-Chi H Li; Tse-Hua Tan; Nancy H Colburn
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

8.  Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion.

Authors:  A N Santhanam; A R Baker; G Hegamyer; D A Kirschmann; N H Colburn
Journal:  Oncogene       Date:  2010-05-24       Impact factor: 9.867

9.  Heterogeneous nuclear ribonucleoprotein C1/C2 controls the metastatic potential of glioblastoma by regulating PDCD4.

Authors:  Young Mi Park; Su Jin Hwang; Kiyoshi Masuda; Kyung-Min Choi; Mi-Ran Jeong; Do-Hyun Nam; Myriam Gorospe; Hyeon Ho Kim
Journal:  Mol Cell Biol       Date:  2012-08-20       Impact factor: 4.272

10.  Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer.

Authors:  N A Wei; Stephanie S Liu; Thomas H Y Leung; Kar F Tam; Xiao Y Liao; Annie N Y Cheung; Karen K L Chan; Hextan Y S Ngan
Journal:  Mol Cancer       Date:  2009-09-03       Impact factor: 27.401
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