Literature DB >> 15153043

The MPEG effect: improving asymmetric processes by simple additives.

Jens Rudolph1, Nina Hermanns, Carsten Bolm.   

Abstract

Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this "MPEG effect" allows a reduction of the catalyst loading by a factor of 10.

Entities:  

Year:  2004        PMID： 15153043     DOI： 10.1021/jo0495079

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

Authors:  Julien Rolland; Xacobe C Cambeiro; Carles Rodríguez-Escrich; Miquel A Pericàs
Journal:  Beilstein J Org Chem       Date:  2009-10-15       Impact factor: 2.883

2.  Practical catalytic asymmetric synthesis of diaryl-, aryl heteroaryl-, and diheteroarylmethanols.

Authors:  Luca Salvi; Jeung Gon Kim; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2009-09-02       Impact factor: 15.419

3.  The catalytic asymmetric addition of alkyl- and aryl-zinc reagents to an isoxazole aldehyde.

Authors:  Jared K Nelson; Brendan Twamley; Trinidad J Villalobos; Nicholas R Natale
Journal:  Tetrahedron Lett       Date:  2008-10-06       Impact factor: 2.415

4.  One-pot multicomponent coupling methods for the synthesis of diastereo- and enantioenriched (Z)-trisubstituted allylic alcohols.

Authors:  Michael H Kerrigan; Sang-Jin Jeon; Young K Chen; Luca Salvi; Patrick J Carroll; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2009-06-24       Impact factor: 15.419

5.  Catalytic asymmetric generation of (Z)-disubstituted allylic alcohols.

Authors:  Luca Salvi; Sang-Jin Jeon; Ethan L Fisher; Patrick J Carroll; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2007-12-04       Impact factor: 15.419
  5 in total

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