BACKGROUND: Two-thirds of colorectal malignancies are localised in the left colon and rectum. Recent studies suggest a trend towards an increase of right-sided tumours which might have important implications for screening and surveillance. A colorectal cancer registry was set up in Modena, northern Italy, with the purpose of examining incidence, subsite distribution and staging of colorectal malignancies over a 15-year period. PATIENTS AND METHODS: From 1984 to 1998, 2517 tumours in 2462 patients were detected and staged with the tumour node metastasis (TNM) system. The 'right colon' was considered from caecum to splenic flexure; the 'left colon' included descending and sigmoid colon; and the 'rectum' included rectosigmoid junction, ampulla and anus. RESULTS: Cancer incidence showed an overall increase. Considering the various subsites, an increase of 33.7% in all colonic segments was shown whereas rectal tumours tended to decline. TNM staging showed a gradual increase of localised lesions (41.2% in 1984 versus 53.3% in 1998), with a proportional reduction of advanced tumours. CONCLUSIONS: Our study indicates an increase of tumour incidence in all colonic segments more than a shift to the right colon. TNM staging tended to improve with an appreciable increase of localised lesions. These findings could be consequent to a more extensive use of colonoscopy.
BACKGROUND: Two-thirds of colorectal malignancies are localised in the left colon and rectum. Recent studies suggest a trend towards an increase of right-sided tumours which might have important implications for screening and surveillance. A colorectal cancer registry was set up in Modena, northern Italy, with the purpose of examining incidence, subsite distribution and staging of colorectal malignancies over a 15-year period. PATIENTS AND METHODS: From 1984 to 1998, 2517 tumours in 2462 patients were detected and staged with the tumour node metastasis (TNM) system. The 'right colon' was considered from caecum to splenic flexure; the 'left colon' included descending and sigmoid colon; and the 'rectum' included rectosigmoid junction, ampulla and anus. RESULTS:Cancer incidence showed an overall increase. Considering the various subsites, an increase of 33.7% in all colonic segments was shown whereas rectal tumours tended to decline. TNM staging showed a gradual increase of localised lesions (41.2% in 1984 versus 53.3% in 1998), with a proportional reduction of advanced tumours. CONCLUSIONS: Our study indicates an increase of tumour incidence in all colonic segments more than a shift to the right colon. TNM staging tended to improve with an appreciable increase of localised lesions. These findings could be consequent to a more extensive use of colonoscopy.
Authors: Vito D Corleto; Cristiano Pagnini; Maria Sofia Cattaruzza; Ermira Zykaj; Emilio Di Giulio; Giovanna Margagnoni; Emanuela Pilozzi; Giancarlo D'Ambra; Antonietta Lamazza; Enrico Fiori; Mario Ferri; Luigi Masoni; Vincenzo Ziparo; Bruno Annibale; Gianfranco Delle Fave Journal: World J Gastroenterol Date: 2012-12-07 Impact factor: 5.742
Authors: Nikol Snoeren; Emile E Voest; Andre M Bergman; Otilia Dalesio; Henk M Verheul; Rob A E M Tollenaar; Joost R M van der Sijp; Sander B Schouten; Inne H M Borel Rinkes; R van Hillegersberg Journal: BMC Cancer Date: 2010-10-11 Impact factor: 4.430
Authors: Gian Franco Adami; Francesco S Papadia; Giuseppe M Marinari; Giovanni B Camerini; Nicola Scopinaro Journal: Obes Surg Date: 2008-01-03 Impact factor: 4.129