Literature DB >> 15151424

What are the limits to the size of effective dynamic combinatorial libraries?

Peter T Corbett1, Sijbren Otto, Jeremy K M Sanders.   

Abstract

Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10(6) compounds. [structure: see text]

Year:  2004        PMID： 15151424     DOI： 10.1021/ol049398k

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Mimicking nature with synthetic macromolecules capable of recognition.

Authors:  Clare S Mahon; David A Fulton
Journal:  Nat Chem       Date:  2014-08       Impact factor: 24.427

2.  Applications of dynamic combinatorial chemistry for the determination of effective molarity.

Authors:  Maria Ciaccia; Irene Tosi; Laura Baldini; Roberta Cacciapaglia; Luigi Mandolini; Stefano Di Stefano; Christopher A Hunter
Journal:  Chem Sci       Date:  2014-09-29       Impact factor: 9.825

3.  Toward in Silico Modeling of Dynamic Combinatorial Libraries.

Authors:  Iuri Casciuc; Artem Osypenko; Bohdan Kozibroda; Dragos Horvath; Gilles Marcou; Fanny Bonachera; Alexandre Varnek; Jean-Marie Lehn
Journal:  ACS Cent Sci       Date:  2022-05-27       Impact factor: 18.728

4.  Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach.

Authors:  Sylvain Ladame; Andrew M Whitney; Shankar Balasubramanian
Journal:  Angew Chem Int Ed Engl       Date:  2005-09-05       Impact factor: 15.336
  4 in total

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