Literature DB >> 15150616

Confounding effect of socioeconomic position in the study of height in relation to prostate cancer risk.

G D Batty.   

Abstract

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Year:  2004        PMID: 15150616      PMCID: PMC2409736          DOI: 10.1038/sj.bjc.6601799

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


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Sir, In their report, Engeland examined height (an indicator of genetic and early life environmental factors) and body mass index (an indicator of overweight) in relation to prostate cancer, finding an elevated risk in men of tall stature and of overweight. While the study offers high power (a total of 33 314 verified cases in a cohort of almost one million men), there was an absence of any collateral data. Both height and overweight are socially patterned, with the highest proportion of taller and leaner adult individuals among the more affluent (Batty and Leon, 2002). Socioeconomic position is also associated with prostate cancer mortality, generally with an elevated risk in the higher social groups (Davey Smith ; Pukkala and Weiderpass, 2002). This raises the question of whether socioeconomic differences in height and overweight may be an alternative explanation for their apparent relation with prostate cancer risk. While recent evidence suggests this is not the case for overweight in relation to prostate cancer (Calle ), two studies (Leon ; Nilsen and Vatten, 1999) that explored the predictive value of height for this malignancy found that the magnitude of the association was attenuated following control for social factors which included educational attainment and occupational social class. All observational studies are hampered by some methodological shortcoming; however, confounding by socioeconomic position is important in the study of cancer aetiology, and may explain the apparent protective effect of short stature on prostate cancer in the present study.
  7 in total

1.  Anthropometry and prostate cancer risk: a prospective study of 22,248 Norwegian men.

Authors:  T I Nilsen; L J Vatten
Journal:  Cancer Causes Control       Date:  1999-08       Impact factor: 2.506

2.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

Authors:  Eugenia E Calle; Carmen Rodriguez; Kimberly Walker-Thurmond; Michael J Thun
Journal:  N Engl J Med       Date:  2003-04-24       Impact factor: 91.245

3.  Adult height and mortality in London: early life, socioeconomic confounding, or shrinkage?

Authors:  D A Leon; G D Smith; M Shipley; D Strachan
Journal:  J Epidemiol Community Health       Date:  1995-02       Impact factor: 3.710

4.  Socio-economic differences in incidence rates of cancers of the male genital organs in Finland, 1971-95.

Authors:  Eero Pukkala; Elisabete Weiderpass
Journal:  Int J Cancer       Date:  2002-12-20       Impact factor: 7.396

5.  Socioeconomic differentials in cancer among men.

Authors:  G D Smith; D Leon; M J Shipley; G Rose
Journal:  Int J Epidemiol       Date:  1991-06       Impact factor: 7.196

Review 6.  Socio-economic position and coronary heart disease risk factors in children and young people. Evidence from UK epidemiological studies.

Authors:  G David Batty; David A Leon
Journal:  Eur J Public Health       Date:  2002-12       Impact factor: 3.367

7.  Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men.

Authors:  A Engeland; S Tretli; T Bjørge
Journal:  Br J Cancer       Date:  2003-10-06       Impact factor: 7.640

  7 in total
  3 in total

1.  Adult height and cancer mortality in Asia: the Asia Pacific Cohort Studies Collaboration.

Authors:  G D Batty; F Barzi; M Woodward; K Jamrozik; J Woo; H C Kim; H Ueshima; R R Huxley
Journal:  Ann Oncol       Date:  2009-11-04       Impact factor: 32.976

2.  Obesity and overweight in relation to disease-specific mortality in men with and without existing coronary heart disease in London: the original Whitehall study.

Authors:  G D Batty; M J Shipley; R J Jarrett; E Breeze; M G Marmot; G Davey Smith
Journal:  Heart       Date:  2005-11-03       Impact factor: 5.994

3.  Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study.

Authors:  L Gray; I-M Lee; H D Sesso; G D Batty
Journal:  Ann Oncol       Date:  2011-06-15       Impact factor: 32.976

  3 in total

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