Literature DB >> 15150287

Presence of collagen IV in the ciliary zonules of the human eye: an immunohistochemical study by LM and TEM.

Leonoor I Los1, Roelofje J van der Worp, Marja J A van Luyn, Johanna M M Hooymans.   

Abstract

The ciliary zonules of the eye are composed of fibrillar and non-fibrillar components. Fibrils provide tensile strength and elasticity, whereas non-fibrillar components serve as a coating surrounding the fibrils. This coating behaves as a barrier to macromolecules. The present light and transmission electron microscopic (LM and TEM) study identified collagen IV as a novel component of this coating. Collagen IV was demonstrated by pre-embedding and postembedding immunohistochemical (IHC) techniques using monoclonal and polyclonal antibodies. The specificity of the polyclonal anticollagen IV antibody was verified by ELISA.

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Year:  2004        PMID: 15150287     DOI: 10.1369/jhc.4A6267.2004

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN: 0022-1554            Impact factor:   2.479


  1 in total

1.  High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.

Authors:  Shikma Mordechai; Libe Gradstein; Annika Pasanen; Rivka Ofir; Khalil El Amour; Jaime Levy; Nadav Belfair; Tova Lifshitz; Sara Joshua; Ginat Narkis; Khalil Elbedour; Johanna Myllyharju; Ohad S Birk
Journal:  Am J Hum Genet       Date:  2011-09-01       Impact factor: 11.025

  1 in total

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