OBJECTIVE: The objective of this study was to evaluate the routine use of gradient-refocused echo MRI sequences in the detection of cortical cerebral microbleeding suggestive of cerebral amyloid angiopathy in elderly patients (> 70 years old). CONCLUSION: The addition of gradient-refocused echo sequences to routine brain MRI resulted in the identification of cerebral amyloid angiopathy-related microbleeding in 15.5% of elderly patients. In most (86.7%) of these patients with positive findings, cerebral amyloid angiopathy was not suspected clinically, and 46.7% of these patients were undergoing anticoagulant or aspirin therapy, placing them at an increased risk of recurrent intracranial hemorrhage and catastrophic stroke.
OBJECTIVE: The objective of this study was to evaluate the routine use of gradient-refocused echo MRI sequences in the detection of cortical cerebral microbleeding suggestive of cerebral amyloid angiopathy in elderly patients (> 70 years old). CONCLUSION: The addition of gradient-refocused echo sequences to routine brain MRI resulted in the identification of cerebral amyloid angiopathy-related microbleeding in 15.5% of elderly patients. In most (86.7%) of these patients with positive findings, cerebral amyloid angiopathy was not suspected clinically, and 46.7% of these patients were undergoing anticoagulant or aspirin therapy, placing them at an increased risk of recurrent intracranial hemorrhage and catastrophic stroke.
Authors: E M Haacke; Z S DelProposto; S Chaturvedi; V Sehgal; M Tenzer; J Neelavalli; D Kido Journal: AJNR Am J Neuroradiol Date: 2007-02 Impact factor: 3.825
Authors: Muhammad Ayaz; Alexander S Boikov; E Mark Haacke; Daniel K Kido; Wolff M Kirsch Journal: J Magn Reson Imaging Date: 2010-01 Impact factor: 4.813
Authors: Susan K Lemieux; Carrie A Smith-Bell; Jered R Wells; Nnadozie M Ezerioha; Jeffrey S Carpenter; D Larry Sparks; Bernard G Schreurs Journal: J Magn Reson Imaging Date: 2010-08 Impact factor: 4.813
Authors: Matthew Schrag; Grant McAuley; Justine Pomakian; Arshad Jiffry; Spencer Tung; Claudius Mueller; Harry V Vinters; E Mark Haacke; Barbara Holshouser; Daniel Kido; Wolff M Kirsch Journal: Acta Neuropathol Date: 2010-03 Impact factor: 17.088