UNLABELLED: Taurine transporter knockout mice show severe retinal degeneration at an early age. The study was designed to determine whether degeneration also takes place in the absence of light. Mice were maintained up to 6 weeks of age in cyclic lighting or in total darkness. Degeneration took place in both groups, but was more rapid in animals exposed to standard cyclic illumination. At the ultrastructural level the retinas showed features characteristic of apoptosis but not of necrosis. CONCLUSIONS: Cell differentiation is not seriously affected by the lack of a functional taurine transporter but mature photoreceptor cells do not survive without an intact transporter, even in the dark.
UNLABELLED: Taurine transporter knockout mice show severe retinal degeneration at an early age. The study was designed to determine whether degeneration also takes place in the absence of light. Mice were maintained up to 6 weeks of age in cyclic lighting or in total darkness. Degeneration took place in both groups, but was more rapid in animals exposed to standard cyclic illumination. At the ultrastructural level the retinas showed features characteristic of apoptosis but not of necrosis. CONCLUSIONS: Cell differentiation is not seriously affected by the lack of a functional taurine transporter but mature photoreceptor cells do not survive without an intact transporter, even in the dark.
Authors: Ana Martínez-Vacas; Johnny Di Pierdomenico; Alejandro Gallego-Ortega; Francisco J Valiente-Soriano; Manuel Vidal-Sanz; Serge Picaud; María Paz Villegas-Pérez; Diego García-Ayuso Journal: Redox Biol Date: 2022-10-14 Impact factor: 10.787
Authors: Sarika Tiwari; Scott Hudson; Vincent H Gattone; Caroline Miller; Ellen A G Chernoff; Teri L Belecky-Adams Journal: PLoS One Date: 2013-03-13 Impact factor: 3.240
Authors: Gayle B Collin; Navdeep Gogna; Bo Chang; Nattaya Damkham; Jai Pinkney; Lillian F Hyde; Lisa Stone; Jürgen K Naggert; Patsy M Nishina; Mark P Krebs Journal: Cells Date: 2020-04-10 Impact factor: 7.666