| Literature DB >> 15149705 |
Jeffrey J Hale1, William Neway, Sander G Mills, Richard Hajdu, Carol Ann Keohane, Mark Rosenbach, James Milligan, Gan-Ju Shei, Gary Chrebet, James Bergstrom, Deborah Card, Gloria C Koo, Sam L Koprak, Jesse J Jackson, Hugh Rosen, Suzanne Mandala.
Abstract
Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration of potent sphingosine-1-phosphate receptor agonists exemplified by 19. The similar S1P receptor profiles of 2 and 19 coupled with their comparable potency in vivo supports a connection between S1P receptor agonism and immunosuppressive efficacy.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15149705 DOI： 10.1016/j.bmcl.2004.02.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823