| Literature DB >> 15149697 |
Takayoshi Suzuki1, Akiyasu Kouketsu, Azusa Matsuura, Arihiro Kohara, Shin-Ichi Ninomiya, Kohfuku Kohda, Naoki Miyata.
Abstract
In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was synthesized, and their inhibitory effect on HDACs was evaluated. Compound 6, in which the hydroxamic acid of SAHA was replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SAHA.Entities:
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Year: 2004 PMID： 15149697 DOI： 10.1016/j.bmcl.2004.03.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823