Literature DB >> 15149690

Simple and an efficient method for the synthesis of 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol hydrochloride: (+/-) venlafaxine racemic mixtures.

C V Kavitha, K S Rangappa.   

Abstract

A novel synthetic method was developed for the synthesis of venlafaxine using inexpensive reagents. An improvement in the method, in the yield was achieved for the conversion of the venlafaxine. This is an improved version, simple and efficient method for the large-scale synthesis of venlafaxine.

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Year:  2004        PMID： 15149690     DOI： 10.1016/j.bmcl.2004.03.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.

Authors:  Chakrabhavi Dhananjaya Mohan; Hanumantharayappa Bharathkumar; Krishna C Bulusu; Vijay Pandey; Shobith Rangappa; Julian E Fuchs; Muthu K Shanmugam; Xiaoyun Dai; Feng Li; Amudha Deivasigamani; Kam M Hui; Alan Prem Kumar; Peter E Lobie; Andreas Bender; Gautam Sethi; Kanchugarakoppal S Rangappa
Journal:  J Biol Chem       Date:  2014-10-15       Impact factor: 5.157

2.  Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells.

Authors:  Swamy Savvemala Girimanchanaika; Dukanya Dukanya; Ananda Swamynayaka; Divya Maldepalli Govindachar; Mahendra Madegowda; Ganga Periyasamy; Kanchugarakoppal Subbegowda Rangappa; Vijay Pandey; Peter E Lobie; Basappa Basappa
Journal:  Int J Mol Sci       Date:  2021-10-12       Impact factor: 5.923

3.  Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase.

Authors:  Divakar Vishwanath; Swamy S Girimanchanaika; Dukanya Dukanya; Shobith Rangappa; Ji-Rui Yang; Vijay Pandey; Peter E Lobie; Basappa Basappa
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

4.  Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule.

Authors:  Kazuyuki Sugahara; Kuntebommanahalli N Thimmaiah; Hemant K Bid; Peter J Houghton; Kanchugarakoppal S Rangappa
Journal:  PLoS One       Date:  2012-08-15       Impact factor: 3.240
  4 in total

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