| Literature DB >> 15149680 |
Christopher G Barber1, Roger P Dickinson, Paul V Fish.
Abstract
A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin. Potency is enhanced by the presence of a 4-halo and a 7-aryl substituent, particularly when substituted by a 3-carboxylic acid group. Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation.Entities:
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Year: 2004 PMID： 15149680 DOI： 10.1016/j.bmcl.2004.03.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823