| Literature DB >> 15149679 |
Ben B Wang1, Nima Maghami, Vanessa L Goodlin, Paul J Smith.
Abstract
Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition.Entities:
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Year: 2004 PMID： 15149679 DOI： 10.1016/j.bmcl.2004.03.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823