Literature DB >> 15149674

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.

Christian Beaulieu1, Zhaoyin Wang, Danielle Denis, Gillian Greig, Sonia Lamontagne, Gary O'Neill, Deborah Slipetz, Jennifer Wang.   

Abstract

A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.

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Year:  2004        PMID： 15149674     DOI： 10.1016/j.bmcl.2004.04.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Diversity-oriented synthesis of benzimidazole, benzoxazole, benzothiazole and quinazolin-4(3H)-one libraries via potassium persulfate-CuSO4-mediated oxidative coupling reactions of aldehydes in aqueous micelles.

Authors:  Atul Kumar; Ram Awatar Maurya; Deepti Saxena
Journal:  Mol Divers       Date:  2009-07-04       Impact factor: 2.943

2.  Straightforward synthesis of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles.

Authors:  Natarajan Arumugam; Aisyah Saad Abdul Rahim; Shafida Abd Hamid; Hasnah Osman
Journal:  Molecules       Date:  2012-08-17       Impact factor: 4.411
  2 in total

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