Literature DB >> 15149671

Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.

Martin Sendzik1, James W Janc, Ronnel Cabuslay, Lee Honigberg, Richard L Mackman, Catherine Magill, Neil Squires, Nancy Waldeck.   

Abstract

The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described.

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Year:  2004        PMID: 15149671     DOI: 10.1016/j.bmcl.2004.04.004

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis and Transformation of (-)-Isopulegol-Based Chiral β-Aminolactones and β-Aminoamides.

Authors:  Tam Minh Le; Péter Bérdi; István Zupkó; Ferenc Fülöp; Zsolt Szakonyi
Journal:  Int J Mol Sci       Date:  2018-11-08       Impact factor: 5.923

Review 2.  Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

Authors:  Zefeng Zhao; Huanhuan Song; Jing Xie; Tian Liu; Xue Zhao; Xufei Chen; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Eur J Med Chem       Date:  2019-04-06       Impact factor: 6.514

  2 in total

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