| Literature DB >> 15149667 |
Martina E Tedder1, Zhe Nie, Stephen Margosiak, Shaosong Chu, Victoria A Feher, Robert Almassy, Krzysztof Appelt, Kraig M Yager.
Abstract
The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.Entities:
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Year: 2004 PMID： 15149667 DOI： 10.1016/j.bmcl.2004.04.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823