| Literature DB >> 15149643 |
Michele C Jetter1, Mark A Youngman, James J McNally, Sui-Po Zhang, Adrienne E Dubin, Nadia Nasser, Scott L Dax.
Abstract
Starting from a low micromolar agonist lead identified by high-throughput screening, series of N-isoquinolin-5-yl-N'-aralkyl ureas and analogous amides were developed as potent antagonists of human vanilloid receptor 1 (VR1). The synthesis and structure-activity relationships (SAR) of the series are described.Entities:
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Year: 2004 PMID： 15149643 DOI： 10.1016/j.bmcl.2004.04.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823