Literature DB >> 15149588

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis.

Michele Pagano1.   

Abstract

A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.

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Year:  2004        PMID： 15149588     DOI： 10.1016/s1097-2765(04)00268-0

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  43 in total

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Review 4.  The ubiquitin-proteasome pathway and plant development.

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Journal:  Plant Cell       Date:  2004-12       Impact factor: 11.277

5.  MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2.

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Review 7.  Liver X receptors as therapeutic targets in metabolism and atherosclerosis.

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8.  Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase.

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Journal:  Cell Cycle       Date:  2011-08-15       Impact factor: 4.534

9.  Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1.

Authors:  H Liu; H Qiu; Y Song; Y Liu; H Wang; M Lu; M Deng; Y Gu; J Yin; K Luo; Z Zhang; X Jia; G Zheng; Z He
Journal:  Oncogene       Date:  2016-10-03       Impact factor: 9.867

10.  The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development.

Authors:  Andi Gusti; Nicolas Baumberger; Moritz Nowack; Stefan Pusch; Herfried Eisler; Thomas Potuschak; Lieven De Veylder; Arp Schnittger; Pascal Genschik
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