M Placzek1, U Kerkmann, S Bell, P Koepke, B Przybilla. 1. Klinik und Poliklinik für Dermatologie and Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstrasse 9-11, 80337 Munich, Germany. mairiann.placzek@lrz.uni-muenchen.de
Abstract
BACKGROUND: Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing. OBJECTIVES: To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke. METHODS: A photohaemolysis test was used, in which human erythrocytes were incubated with cigarette smoke condensate, followed by UV irradiation and measurement of exposure-dependent haemolysis. RESULTS: Cigarette smoke condensate was clearly phototoxic. Photohaemolysis depended on the concentration of the condensate and UV dose and was more pronounced after exposure to UVA-rich than UVB-rich radiation. CONCLUSIONS: Phototoxicity may be a mechanism by which cigarette smoking causes premature skin ageing. An enhancing effect on photocarcinogenesis has also to be considered.
BACKGROUND: Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing. OBJECTIVES: To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke. METHODS: A photohaemolysis test was used, in which human erythrocytes were incubated with cigarette smoke condensate, followed by UV irradiation and measurement of exposure-dependent haemolysis. RESULTS: Cigarette smoke condensate was clearly phototoxic. Photohaemolysis depended on the concentration of the condensate and UV dose and was more pronounced after exposure to UVA-rich than UVB-rich radiation. CONCLUSIONS: Phototoxicity may be a mechanism by which cigarette smoking causes premature skin ageing. An enhancing effect on photocarcinogenesis has also to be considered.
Authors: Iñigo Rúa-Figueroa; Celia Erausquin; Celia Rua-Figueroa; Jesús González-Martín; Antonio Naranjo; Soledad Ojeda; Félix Francisco; Juan C Quevedo; Laura Cáceres; Ruben López; Martin Greco; Irene Altabás-González; Yanira Pérez; Francisco Rubiño; Carlos Rodríguez-Lozano Journal: Rheumatol Int Date: 2019-11-27 Impact factor: 2.631
Authors: Evan W Piette; Kristen P Foering; Aileen Y Chang; Joyce Okawa; Thomas R Ten Have; Rui Feng; Victoria P Werth Journal: Arch Dermatol Date: 2011-11-21