Xiangyi Zheng1, Wei Ding, Liping Xie, Zhaodian Chen. 1. Department of Urology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310003, China. zhengxy@hz.cn
Abstract
OBJECTIVE: To investigate the expression of activated leukocyte cell adhesion molecule(ALCAM) protein in prostatic intraepithelial neoplasia and adenocarcinoma, and the relationship between ALCAM expression and clinicopathological features of prostatic carcinoma. METHODS: ALCAM protein expression was evaluated in the tissues of 41 human prostatic carcinomas by using immunohistochemistry (EnVision method). RESULTS: ALCAM was widely expressed in prostatic epithelia. Overexpression of ALCAM was found in most prostatic intraepithelial neoplasias and low-grade cancers, whereas a decreased expression shown in some high-grade cancers. The ALCAM protein expression in prostatic carcinoma was correlated with pathological grading. However, no correlation of ALCAM expression was found with preoperative serum prostate-specific antigen levels or clinical stages. CONCLUSION: Expression of ALCAM is disturbed in prostatic intraepithelial neoplasia and adenocarcinoma, indicating its involvement in the development of human prostatic carcinoma.
OBJECTIVE: To investigate the expression of activated leukocyte cell adhesion molecule(ALCAM) protein in prostatic intraepithelial neoplasia and adenocarcinoma, and the relationship between ALCAM expression and clinicopathological features of prostatic carcinoma. METHODS:ALCAM protein expression was evaluated in the tissues of 41 humanprostatic carcinomas by using immunohistochemistry (EnVision method). RESULTS:ALCAM was widely expressed in prostatic epithelia. Overexpression of ALCAM was found in most prostatic intraepithelial neoplasias and low-grade cancers, whereas a decreased expression shown in some high-grade cancers. The ALCAM protein expression in prostatic carcinoma was correlated with pathological grading. However, no correlation of ALCAM expression was found with preoperative serum prostate-specific antigen levels or clinical stages. CONCLUSION: Expression of ALCAM is disturbed in prostatic intraepithelial neoplasia and adenocarcinoma, indicating its involvement in the development of humanprostatic carcinoma.
Authors: Judy A King; Fang Tan; Flaubert Mbeunkui; Zachariah Chambers; Sarah Cantrell; Hairu Chen; Diego Alvarez; Lalita A Shevde; Solomon F Ofori-Acquah Journal: Mol Cancer Date: 2010-10-07 Impact factor: 27.401