| Literature DB >> 15148409 |
Kiyotoshi Satoh1, Mana Kasai, Takefumi Ishidao, Kenichi Tago, Susumu Ohwada, Yoshimi Hasegawa, Takao Senda, Shinji Takada, Shigeyuki Nada, Tsutomu Nakamura, Tetsu Akiyama.
Abstract
Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor. Here we show that ICAT(-/-) embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT(-/-) embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.Entities:
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Year: 2004 PMID： 15148409 PMCID： PMC419549 DOI： 10.1073/pnas.0401733101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205