Literature DB >> 15148139

Therapy for nerve agent poisoning.

Jonathan Newmark1.   

Abstract

Neurologists need to familiarize themselves with nerve agents, the most toxic of the chemical warfare agents. Their mode of action lies within the nervous system, and nonneurologists will look to neurologists for expert advice on therapy. These agents cause rapid-onset cholinergic crisis amenable to prompt treatment with specific antidotes. Experience on the battlefield and in terrorist attacks demonstrates that therapy saves lives.

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Year:  2004        PMID: 15148139     DOI: 10.1001/archneur.61.5.649

Source DB:  PubMed          Journal:  Arch Neurol        ISSN: 0003-9942


  20 in total

1.  A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity.

Authors:  Vesna A Eterović; Dinely Pérez; Antonio H Martins; Brenda L Cuadrado; Marimée Carrasco; P A Ferchmin
Journal:  Toxicol In Vitro       Date:  2011-05-04       Impact factor: 3.500

2.  Neuroprotection Against Diisopropylfluorophosphate in Acute Hippocampal Slices.

Authors:  P A Ferchmin; Dinely Pérez; Brenda L Cuadrado; Marimée Carrasco; Antonio H Martins; Vesna A Eterović
Journal:  Neurochem Res       Date:  2015-10-05       Impact factor: 3.996

3.  Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons.

Authors:  Yushan Wang; Lidong Liu; Tracy Weiss; Christine Stewart; John Mikler
Journal:  Neurotox Res       Date:  2011-06-04       Impact factor: 3.911

4.  Differential binding of bispyridinium oxime drugs with acetylcholinesterase.

Authors:  Manoj K Kesharwani; Bishwajit Ganguly; Amit Das; Tusar Bandyopadhyay
Journal:  Acta Pharmacol Sin       Date:  2010-02-08       Impact factor: 6.150

5.  Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun.

Authors:  Christopher D Fleming; Carol C Edwards; Stephen D Kirby; Donald M Maxwell; Philip M Potter; Douglas M Cerasoli; Matthew R Redinbo
Journal:  Biochemistry       Date:  2007-04-04       Impact factor: 3.162

6.  Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.

Authors:  Daniel Jun; Lucie Musilova; Miroslav Pohanka; Young-Sik Jung; Pavel Bostik; Kamil Kuca
Journal:  Int J Mol Sci       Date:  2010-08-03       Impact factor: 5.923

7.  Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX.

Authors:  Xiugong Gao; Hsiuling Lin; Radharaman Ray; Prabhati Ray
Journal:  Neurochem Res       Date:  2013-02-26       Impact factor: 3.996

8.  Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat.

Authors:  Thomas H Snider; Kevin G McGarry; Michael C Babin; David A Jett; Gennady E Platoff; David T Yeung
Journal:  Fundam Toxicol Sci       Date:  2016

9.  An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

Authors:  Shan Jin; Kumar S Sarkar; Youngnam N Jin; Yan Liu; David Kokel; Tjakko J Van Ham; Lee D Roberts; Robert E Gerszten; Calum A Macrae; Randall T Peterson
Journal:  J Biomol Screen       Date:  2012-09-06

10.  Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling.

Authors:  Vesna A Eterović; Angelie Del Valle-Rodriguez; Dinely Pérez; Marimée Carrasco; Mohammad A Khanfar; Khalid A El Sayed; Pedro A Ferchmin
Journal:  Bioorg Med Chem       Date:  2013-05-24       Impact factor: 3.641

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