| Literature DB >> 15147905 |
Scott J Cameron1, Seigo Itoh, Christopher P Baines, Changxi Zhang, Shinsuke Ohta, Wenyi Che, Michael Glassman, Jiing-Dwan Lee, Chen Yan, Jay Yang, Jun-ichi Abe.
Abstract
Big MAP kinase 1 (BMK1/ERK5) plays a critical role in pre-natal development of the cardiovascular system and post-natal eccentric hypertrophy of the heart. Of the two isoforms upstream of MAPK-kinase 5 (MEK5) known to exist, only the longer MEK5alpha isoform potently activates BMK1. We generated cardiac-specific constitutively active form of the MEK5alpha (CA-MEK5alpha transgenic (Tg) mice), and observed a 3 to 4-fold increase in endogenous BMK1 activation and hyperphosphorylation of connexin 43 in the ventricles of the Tg compared to wild-type mice. The CA-MEK5alpha-Tg-mice demonstrated a profoundly accelerated recovery of left ventricular developed pressure after ischemia/reperfusion. We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury.Entities:
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Year: 2004 PMID： 15147905 DOI： 10.1016/j.febslet.2004.03.120
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124