| Literature DB >> 15147884 |
Regina A Menezes1, Catarina Amaral, Agnès Delaunay, Michel Toledano, Claudina Rodrigues-Pousada.
Abstract
Yap8p, a member of the Saccharomyces cerevisiae Yap family, is activated in response to arsenic. Both the mechanisms by which this activation takes place and its regulation have not yet been identified. In this report, we show that Yap8p is not activated at the transcriptional level but, rather, its nuclear transport is actively regulated and dependent on the exportin chromosome region maintenance protein. In addition, it is shown that Cys(132), Cys(137)and Cys(274) are essential for Yap8p localization and transactivation function both of which are required for its biological activity.Entities:
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Year: 2004 PMID： 15147884 DOI： 10.1016/j.febslet.2004.04.019
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124