Literature DB >> 15147329

Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease.

G Pasterkamp1, J K Van Keulen, D P V De Kleijn.   

Abstract

The family of Toll-like receptors (TLRs) initiates an innate immune response after recognition of pathogen-associated molecular patterns (PAMPs). Evidence is accumulating that TLRs, and particularly TLR4, are important players in the initiation and progression of atherosclerotic disease. Not only exogenous ligands but also endogenous ligands that are expressed during arterial injury are recognized by TLR4. Mouse knockout studies and epidemiological studies of human TLR4 polymorphisms have demonstrated that the TLR4 might play a role in the initiation and progression of atherosclerosis. This review will summarize the latest progression in research on the role of TLR4 in arterial occlusive disease In addition, the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed.

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Year:  2004        PMID： 15147329     DOI： 10.1111/j.1365-2362.2004.01338.x

Source DB:  PubMed          Journal:  Eur J Clin Invest        ISSN： 0014-2972            Impact factor:   4.686


  44 in total

Review 1.  TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases.

Authors:  Carmela Rita Balistreri; Giuseppina Colonna-Romano; Domenico Lio; Giuseppina Candore; Calogero Caruso
Journal:  J Clin Immunol       Date:  2009-05-21       Impact factor: 8.317

2.  Increased expression of Toll like receptor 4 on peripheral-blood mononuclear cells in patients with coronary arteriosclerosis disease.

Authors:  H-L Geng; H-Q Lu; L-Z Zhang; H Zhang; L Zhou; H Wang; R-Q Zhong
Journal:  Clin Exp Immunol       Date:  2006-02       Impact factor: 4.330

Review 3.  Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.

Authors:  Charlotte Spitz; Holger Winkels; Christina Bürger; Christian Weber; Esther Lutgens; Göran K Hansson; Norbert Gerdes
Journal:  Cell Mol Life Sci       Date:  2015-10-30       Impact factor: 9.261

4.  Association of blood monocyte and platelet markers with carotid artery characteristics: the atherosclerosis risk in communities carotid MRI study.

Authors:  N Matijevic; K K Wu; A G Howard; B Wasserman; W Y-W Wang; A R Folsom; A R Sharrett
Journal:  Cerebrovasc Dis       Date:  2011-04-12       Impact factor: 2.762

5.  Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle.

Authors:  Rosario Jimenez; Elizabeth Belcher; Shiranee Sriskandan; Ruth Lucas; Shaun McMaster; Ivana Vojnovic; Timothy D Warner; Jane A Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-08       Impact factor: 11.205

6.  Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice.

Authors:  K R Coenen; M L Gruen; R S Lee-Young; M J Puglisi; D H Wasserman; A H Hasty
Journal:  Diabetologia       Date:  2008-12-04       Impact factor: 10.122

7.  Genetic variation and atherosclerosis.

Authors:  Erik Biros; Mirko Karan; Jonathan Golledge
Journal:  Curr Genomics       Date:  2008-03       Impact factor: 2.236

8.  Common genetic variation, residential proximity to traffic exposure, and left ventricular mass: the multi-ethnic study of atherosclerosis.

Authors:  Victor C Van Hee; Sara D Adar; Adam A Szpiro; R Graham Barr; Ana Diez Roux; David A Bluemke; Lianne Sheppard; Edward A Gill; Hossein Bahrami; Christina Wassel; Michele M Sale; David S Siscovick; Jerome I Rotter; Stephen S Rich; Joel D Kaufman
Journal:  Environ Health Perspect       Date:  2010-03-22       Impact factor: 9.031

Review 9.  Pre-clinical and clinical evaluation of nuclear tracers for the molecular imaging of vulnerable atherosclerosis: an overview.

Authors:  L M Riou; A Broisat; J Dimastromatteo; G Pons; D Fagret; C Ghezzi
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

10.  Effects of chronic mild stress on the development of atherosclerosis and expression of toll-like receptor 4 signaling pathway in adolescent apolipoprotein E knockout mice.

Authors:  Hongfeng Gu; Chaoke Tang; Kuang Peng; Hui Sun; Yongzong Yang
Journal:  J Biomed Biotechnol       Date:  2009-08-27
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