BACKGROUND: The objective in this study was to assess the association of gastroesophageal reflux disease (GERD) with asthma in pediatric patients. METHODS: Thirty-six pediatric patients who were diagnosed as having bronchial asthma were included in the study. The male-to-female ratio was 2 to 1. The diagnosis of GER was made by 24-hour pH monitoring. RESULTS: GER was present in 27 of 36 (75%) patients, of whom 19 (70%) were male and 8 (30%) were female patients. The GER frequency was found to be different between the supine and upright positions (p < 0.05). GER was more frequent in the upright position. However, duration of GER was longer in the supine position than the upright position (p < 0.05). Overall reflux duration was similar in both positions (p > 0.05). CONCLUSIONS: Demonstration of the relationship between asthma and GER suggests that GER is involved substantially in the pathogenesis and/or symptomatology of asthma. The patients with asthma should be evaluated for the presence of GER even in the absence of GER-related symptoms.
BACKGROUND: The objective in this study was to assess the association of gastroesophageal reflux disease (GERD) with asthma in pediatric patients. METHODS: Thirty-six pediatric patients who were diagnosed as having bronchial asthma were included in the study. The male-to-female ratio was 2 to 1. The diagnosis of GER was made by 24-hour pH monitoring. RESULTS:GER was present in 27 of 36 (75%) patients, of whom 19 (70%) were male and 8 (30%) were female patients. The GER frequency was found to be different between the supine and upright positions (p < 0.05). GER was more frequent in the upright position. However, duration of GER was longer in the supine position than the upright position (p < 0.05). Overall reflux duration was similar in both positions (p > 0.05). CONCLUSIONS: Demonstration of the relationship between asthma and GER suggests that GER is involved substantially in the pathogenesis and/or symptomatology of asthma. The patients with asthma should be evaluated for the presence of GER even in the absence of GER-related symptoms.
Authors: David F Woods; Stephanie Flynn; Jose A Caparrós-Martín; Stephen M Stick; F Jerry Reen; Fergal O'Gara Journal: Antibiotics (Basel) Date: 2021-06-24