Literature DB >> 15146190

A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity.

Susana Mato1, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E Castillo, Olivier J Manzoni.   

Abstract

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

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Year:  2004        PMID： 15146190     DOI： 10.1038/nn1251

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  82 in total

1.  Are CB(1) Receptor Antagonists Nootropic or Cognitive Impairing Agents?

Authors:  Stephen A Varvel; Laura E Wise; Aron H Lichtman
Journal:  Drug Dev Res       Date:  2009-12-01       Impact factor: 4.360

2.  Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus.

Authors:  Jaclyn I Wamsteeker; J Brent Kuzmiski; Jaideep S Bains
Journal:  J Neurosci       Date:  2010-08-18       Impact factor: 6.167

3.  Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.

Authors:  Brad A Grueter; Gabor Brasnjo; Robert C Malenka
Journal:  Nat Neurosci       Date:  2010-11-14       Impact factor: 24.884

Review 4.  Endocannabinoid signalling in reward and addiction.

Authors:  Loren H Parsons; Yasmin L Hurd
Journal:  Nat Rev Neurosci       Date:  2015-09-16       Impact factor: 34.870

5.  Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation.

Authors:  Alexander F Hoffman; Murat Oz; Ruiqin Yang; Aron H Lichtman; Carl R Lupica
Journal:  Learn Mem       Date:  2007-01-03       Impact factor: 2.460

6.  Group I mGluRs and long-term depression: potential roles in addiction?

Authors:  Brad A Grueter; Zoé A McElligott; Danny G Winder
Journal:  Mol Neurobiol       Date:  2007-07-27       Impact factor: 5.590

7.  Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.

Authors:  Tanya L Daigle; Christopher S Kearn; Ken Mackie
Journal:  Neuropharmacology       Date:  2007-06-26       Impact factor: 5.250

8.  Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.

Authors:  Catherine Orr; Philip Spechler; Zhipeng Cao; Matthew Albaugh; Bader Chaarani; Scott Mackey; Deepak D'Souza; Nicholas Allgaier; Tobias Banaschewski; Arun L W Bokde; Uli Bromberg; Christian Büchel; Erin Burke Quinlan; Patricia Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Penny Gowland; Andreas Heinz; Bernd Ittermann; Jean-Luc Martinot; Marie-Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Tomáš Paus; Luise Poustka; Sabina Millenet; Juliane H Fröhner; Rajiv Radhakrishnan; Michael N Smolka; Henrik Walter; Robert Whelan; Gunter Schumann; Alexandra Potter; Hugh Garavan
Journal:  J Neurosci       Date:  2019-01-14       Impact factor: 6.167

9.  Altered Corticolimbic Control of the Nucleus Accumbens by Long-term Δ9-Tetrahydrocannabinol Exposure.

Authors:  Eun-Kyung Hwang; Carl R Lupica
Journal:  Biol Psychiatry       Date:  2019-08-06       Impact factor: 13.382

10.  Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.

Authors:  Giuseppe Tortoriello; Claudia V Morris; Alan Alpar; Janos Fuzik; Sally L Shirran; Daniela Calvigioni; Erik Keimpema; Catherine H Botting; Kirstin Reinecke; Thomas Herdegen; Michael Courtney; Yasmin L Hurd; Tibor Harkany
Journal:  EMBO J       Date:  2014-01-27       Impact factor: 11.598
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