| Literature DB >> 15145762 |
Nádia Aléssio Velloso Bellé1, Gerusa Duarte Dalmolin, Graciela Fonini, Maribel Antonello Rubin, João Batista Teixeira Rocha.
Abstract
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the free radical and/or aldehyde scavenger effects of polyamines spermine and spermidine on thiobarbituric acid reactive species (TBARS) production induced by QA, SNP, Fe+2/EDTA system and free Fe2+ in rat brain. Spermine and spermidine inhibited QA-induced TBARS production; however spermine was a better antioxidant than spermidine. Spermine also inhibited SNP-, Fe+2/EDTA- and free Fe2+-induced TBARS production, but had a modest effect. Spermidine, in turn, also discretely inhibited SNP-, Fe+2/EDTA- and free Fe2+-induced TBARS production. In the presence of MK-801, QA-induced TBARS production was considerably more inhibited by polyamines. In addition, arcaine does not affect the reducer effect of polyamines. The present findings suggest that the observed effects of polyamines are not related to the activation of NMDA receptor but with their antioxidant and free radical scavenger properties. Copyright 2004 Elsevier B.V.Entities:
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Year: 2004 PMID： 15145762 DOI： 10.1016/j.brainres.2004.02.036
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252