| Literature DB >> 15145460 |
Jemima C Stockton1, Joanna M M Howson, Agnes A Awomoyi, Keith P McAdam, Jenefer M Blackwell, Melanie J Newport.
Abstract
The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.Entities:
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Year: 2004 PMID： 15145460 DOI： 10.1016/j.femsim.2004.02.004
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244