BACKGROUND: Burn associated local and general tissue edema is induced by local cell destruction and capillary leak syndrome. Vascular endothelial growth factor (VEGF) strongly enhances vascular permeability as well as angiogenesis. The principal aim of this study was to investigate the systemic release of VEGF and its kinetics after severe burn injury in humans. METHODS: Thirty-six burn patients and 42 healthy volunteers were enrolled in this study. Circulating VEGF serum levels were measured by enzyme-linked immunosorbent assay at days 1, 3, 7, 14, 21, 28 and 35. Burn surface, tissue edema, complications and outcome were evaluated. RESULTS: VEGF serum levels were significantly increased after burn injuries immediately after injury until wound closure. VEGF levels reached their maximum at day 14 and were 22-fold increased compared to VEGF levels of healthy controls. After wound closure VEGF levels normalized. Local and general tissue edema disappeared after VEGF serum level normalization. CONCLUSIONS: VEGF serum levels are immediately enhanced after burn trauma until wound closure. At the same time, a local and general tissue edema was detected. We may speculate, that specific blockers of VEGF may have beneficial effects on edema and edema-related complications in severe burn patients.
BACKGROUND: Burn associated local and general tissue edema is induced by local cell destruction and capillary leak syndrome. Vascular endothelial growth factor (VEGF) strongly enhances vascular permeability as well as angiogenesis. The principal aim of this study was to investigate the systemic release of VEGF and its kinetics after severe burn injury in humans. METHODS: Thirty-six burn patients and 42 healthy volunteers were enrolled in this study. Circulating VEGF serum levels were measured by enzyme-linked immunosorbent assay at days 1, 3, 7, 14, 21, 28 and 35. Burn surface, tissue edema, complications and outcome were evaluated. RESULTS:VEGF serum levels were significantly increased after burn injuries immediately after injury until wound closure. VEGF levels reached their maximum at day 14 and were 22-fold increased compared to VEGF levels of healthy controls. After wound closure VEGF levels normalized. Local and general tissue edema disappeared after VEGF serum level normalization. CONCLUSIONS:VEGF serum levels are immediately enhanced after burn trauma until wound closure. At the same time, a local and general tissue edema was detected. We may speculate, that specific blockers of VEGF may have beneficial effects on edema and edema-related complications in severe burn patients.
Authors: Heli Lagus; Esko Kankuri; Kristo Nuutila; Susanna Juteau; Maarit Sarlomo-Rikala; Jyrki Vuola Journal: World J Surg Date: 2018-04 Impact factor: 3.352
Authors: Andrew W Wong; Brett Z Fite; Yu Liu; Azadeh Kheirolomoom; Jai W Seo; Katherine D Watson; Lisa M Mahakian; Sarah M Tam; Hua Zhang; Josquin Foiret; Alexander D Borowsky; Katherine W Ferrara Journal: J Clin Invest Date: 2015-11-23 Impact factor: 14.808
Authors: Lyn M Wise; Gabriella S Stuart; Nicola C Real; Stephen B Fleming; Andrew A Mercer Journal: Adv Wound Care (New Rochelle) Date: 2018-08-01 Impact factor: 4.730